Site-Selective, Photocatalytic Vinylogous Amidation of Enones
Kitti Franciska Szabó, Katarzyna Goliszewska, Jakub Szurmak, Katarzyna Rybicka‐Jasińska, Dorota Gryko
Abstract
High Resolution Image Download MS PowerPoint Slide Despite the broad interest in organic compounds possessing a γ-aminocarbonyl motif, limited strategies for their synthesis have been reported. Herein, we describe a mild and efficient method for the site-selective amidation of unsaturated enones with electrophilic N-centered radicals as a key intermediate. The photocatalytic vinylogous reaction of dienolates with N -amino pyridinium salts affords γ-amido carbonyl compounds. This process is high-yielding, scalable, and tolerates a broad range of unsaturated α,β-unsaturated carbonyls, including biologically relevant compounds, as starting materials.