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PCNA inhibition enhances the cytotoxicity of β-lapachone in NQO1-Positive cancer cells by augmentation of oxidative stress-induced DNA damage

Xiaolin Su, Jiangwei Wang, Lingxiang Jiang, Yaomin Chen, Tao Lu, Marc S. Mendonca, Xiumei Huang

2021Cancer Letters18 citationsDOIOpen Access PDF

Topics & Concepts

Proliferating cell nuclear antigenDNA damageDNA repairCytotoxicityCancer researchCell cycleCancer cellBiologyDNA replicationOxidative stressCell growthDNAApoptosisMolecular biologyChemistryCancerBiochemistryIn vitroGeneticsBioactive Compounds and Antitumor AgentsCancer therapeutics and mechanismsSynthesis and Biological Evaluation
PCNA inhibition enhances the cytotoxicity of β-lapachone in NQO1-Positive cancer cells by augmentation of oxidative stress-induced DNA damage | Litcius