Utility of a safety switch to abrogate CD19.CAR T-cell–associated neurotoxicity
Matthew C. Foster, Barbara Savoldo, Winnie Lau, Clio Rubiños, Natalie S. Grover, Paul M. Armistead, James M. Coghill, Robert S. Hagan, Kaitlin Morrison, Faith Brianne Buchanan, Catherine Cheng, Spencer Laing, Anastasia Ivanova, John A. West, Aaron E. Foster, Jonathan S. Serody, Gianpietro Dotti
Abstract
2] Although many cases of ICANS resolve with supportive measures, high-grade ICANS may result in status epilepticus, lasting neurologic deficits, cerebral edema, 6 and death. 7 Therefore, novel approaches for severe ICANS fill an urgent unmet need to enhance the use of adoptive cellular therapy.
Topics & Concepts
MedicineCAR-T cell therapy researchIntegrated Circuits and Semiconductor Failure Analysis