Discovery of novel pyrrolo [2,3-d] pyrimidine derivatives as potent FAK inhibitors based on cyclization strategy
Shenxin Zeng, Shuai Yuan, Yu Zhang, Jinbei Du, Yuhao Wu, Yinqiao Chen, Peizhen Zhu, Wenhai Huang
Topics & Concepts
ChemistryFocal adhesionA549 cellTyrosine kinaseIC50Cancer researchApoptosisKinaseReceptor tyrosine kinaseMetastasisCancer cellReceptorPharmacologySignal transductionCancerBiochemistryIn vitroBiologyInternal medicineMedicineCell Adhesion Molecules ResearchCellular Mechanics and InteractionsUbiquitin and proteasome pathways