Optimal linkage disequilibrium splitting
Florian Privé
Abstract
MOTIVATION: A few algorithms have been developed for splitting the genome in nearly independent blocks of linkage disequilibrium. Due to the complexity of this problem, these algorithms rely on heuristics, which makes them suboptimal. RESULTS: Here, we develop an optimal solution for this problem using dynamic programming. AVAILABILITY: This is now implemented as function snp_ldsplit as part of R package bigsnpr. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
Topics & Concepts
Linkage disequilibriumLinkage (software)DisequilibriumComputer scienceGeneticsComputational biologyBiologyHaplotypeAlleleMedicineGeneOphthalmologyPeroxisome Proliferator-Activated ReceptorsOptimization and Search ProblemsLipid metabolism and biosynthesis