Nanotherapeutic Potential of Antibacterial Folic Acid-Functionalized Nanoceria for Wound-Healing Applications
Kunal Sarkar, Kaushik Dutta, Arindam Chatterjee, Jit Sarkar, Dipankar Das, Arbind Prasad, Dipankar Chattopadhyay, Krishnendu Acharya, Madhusudan Das, Suresh K. Verma, S. S. De
Abstract
Aim: The functionalization and characterization of antibacterial nanoceria with folic acid (FA) and elucidation of their in vivo wound healing application. Materials & methods: Functionalization of nanoceria were done with FA using a chemical method and their antibacterial activity, cellular biocompatibility and in vivo wound healing application were evaluated. Results: The functionalization of nanoceria with FA was done with 10 to 20 nm size and -20.1 mV zeta potential. The nanoformulation showed a bacteriostatic effect along with biocompatibility to different cell lines; 0.1% w/v spray of FA-nanoceria demonstrated excellent wound healing capacity within 14 days in a Wister rat model. Conclusion: The antioxidant and reactive oxygen species scavenging activity of the FA-nanoceria make it a promising therapeutic agent as a unique spray formulation in wound healing applications.