Novel Hyaluronic Acid ethosomes based gel formulation for topical use with reduced toxicity, better skin permeation, deposition, and improved pharmacodynamics
Tushit Sharma, Shubham Thakur, Manjot Kaur, Amrinder Singh, Subheet Kumar Jain
Abstract
anti-ageing effect of optimised ethosomal gel on rats was found to be greater when compared to commercial formulation of HA and the developed carrier-based system proved to deliver the HA molecule in very small amounts into the systemic circulation. The results endorse the ethosomal carrier-based formulation of HA as a attractive technique for better local bioavailability of HA.
Topics & Concepts
PermeationIn vivoEx vivoHuman skinMaterials scienceHyaluronic acidNanocarriersChromatographyBiomedical engineeringZeta potentialLiposomeChemistryMembraneNanotechnologyIn vitroNanoparticleMedicineBiochemistryBiotechnologyBiologyGeneticsAnatomyAdvancements in Transdermal Drug DeliveryOcular Surface and Contact LensDermatology and Skin Diseases