Halogen-bond-promoted direct cross-coupling of ethyl 3-bromo-3-alkyl-2,2-difluoropropanoates with coumarins/quinolinones
Guoliang Pu, Shi-Yuan Song, Yang Jian, Peng Guo, Jia Jia, Peijun Liu, Peijun Liu, Xuefei Li, Ping Liu, Ping Liu, Chun‐Yang He
Abstract
A practical method for the cross-coupling of ethyl 3-bromo-3-alkyl-2,2-difluoropropanoates with coumarins/quinolinones was developed. The IC 50 values of 3l against Huh-7 and A549 cells were determined to be 4.6 μM and 6.8 μM, respectively.
Topics & Concepts
ChemistryAlkylHalogenHalogen bondCoupling (piping)Combinatorial chemistryMedicinal chemistryOrganic chemistryStereochemistryMechanical engineeringEngineeringFluorine in Organic ChemistrySynthesis and Reactions of Organic CompoundsSynthesis and Biological Evaluation