Tomato-fruit-derived extracellular vesicles inhibit <i>Fusobacterium nucleatum via</i> lipid-mediated mechanism
Bao‐Hong Lee, She‐Ching Wu, Hao-Yuan Chien, Tang‐Long Shen, Wei-Hsuan Hsu
Abstract
in a simulator of the gut microbiota fermentation model. Phospholipid analysis of tomato EV revealed that the anti-bacterial effect of tomato-EV was driven by the presence of specific lipids in the EV, as demonstrated by lipid depletion and reconstitution experiments. The findings suggest the potential of tomato-derived EV for treating gut microbiota dysbiosis and preventing intestinal bacterial infections.
Topics & Concepts
Fusobacterium nucleatumDysbiosisMicrobiologyProbioticBiologyExtracellularGut floraLactobacillusChemistryBacteriaBiochemistryFermentationGeneticsPorphyromonas gingivalisExtracellular vesicles in diseaseBurkholderia infections and melioidosisIon Channels and Receptors