Macrophage membrane‒biomimetic nanoparticles target inflammatory microenvironment for epilepsy treatment
Chao Geng, Xing‐Hui Ren, Peipei Cao, Xiaoqi Chu, Penghu Wei, Quanlei Liu, Yongchang Lu, Bin Fu, Wen‐You Li, Yuhao Li, Guoguang Zhao
Abstract
MA@RT-HMSNs target inflammatory foci to inhibit death-related protein kinase 1 and exert antiepileptic effects. This study provides a promising biomimetic nanodelivery system for targeted epilepsy therapy.
Topics & Concepts
MacrophageEpilepsyInflammationNanoparticleMembraneChemistryCell biologyMedicineNeuroscienceNanotechnologyImmunologyBiologyMaterials scienceIn vitroBiochemistryNanoparticle-Based Drug DeliveryRNA Interference and Gene DeliveryMicroRNA in disease regulation