Ergothioneine improves cognitive function by ameliorating mitochondrial damage and decreasing neuroinflammation in a <scp>d</scp>-galactose-induced aging model
F Chen, Botao Wang, Xin Sun, Yage Wang, Ruiyan Wang, Kaikai Li
Abstract
the Nrf2/HO-1 pathway. In addition, EGT could alleviate mitochondrial function by regulating the AMPK/SIRT1/PGC-1α pathway, which in turn attenuated D-galactose induced hippocampal neuronal injury and improved the learning and memory abilities in mice. This study provides a potential dietary strategy to improve age-induced memory impairment.
Topics & Concepts
ErgothioneineNeuroinflammationFunction (biology)CognitionNeuroscienceChemistryMitochondrionGalactoseCognitive agingCell biologyPsychologyBiochemistryBiologyMedicineInternal medicineInflammationAntioxidantAntioxidants, Aging, Portulaca oleraceaTryptophan and brain disordersBiochemical effects in animals