Sonodynamic-immunomodulatory nanostimulators activate pyroptosis and remodel tumor microenvironment for enhanced tumor immunotherapy
Zhuang Chen, Weijing Liu, Zuo Yang, Yi Luo, Chaoqiang Qiao, Anna Xie, Qian Jia, Peng Yang, Zhongliang Wang, Ruili Zhang
Abstract
Our findings indicate that sonodynamic-immunomodulatory pyroptotic strategy exhibits robust anti-tumor immune efficacy as well as provides novel insights into the role of pyroptosis in cancer immunology.
Topics & Concepts
PyroptosisTumor microenvironmentImmune systemImmunotherapyCancer immunotherapyCancer researchSonodynamic therapyInflammasomeChemistryCell biologyMedicineApoptosisImmunologyInflammationBiologyBiochemistryNanoplatforms for cancer theranosticsHydrogen's biological and therapeutic effectsUltrasound and Hyperthermia Applications