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Quercetin-derived microbial metabolite DOPAC potentiates CD8+ T cell anti-tumor immunity via NRF2-mediated mitophagy

Penghu Han, Shuzheng Chu, Jing Shen, Lixiang Li, Yan Zhang, Shiguan Wang, Shiguan Wang, Yangchun Ma, Xiaolong Tang, Chao Gao, Xiangyun Zheng, Bowen Xu, Qiong Wang, Detian Yuan, Shiyang Li, Shiyang Li

2025Cell Metabolism15 citationsDOI

Topics & Concepts

Immune systemMitophagyMetaboliteT cellTumor microenvironmentChemistryImmune checkpointCell biologyMediatorImmunityCancer cellBiochemistryCellCancer immunotherapyBiologyCancerCancer researchTumor necrosis factor alphaMitochondrionMetabolismAxenicImmunotherapyCompartment (ship)CatabolismGut floraGenomics, phytochemicals, and oxidative stressToxin Mechanisms and ImmunotoxinsGinseng Biological Effects and Applications
Quercetin-derived microbial metabolite DOPAC potentiates CD8+ T cell anti-tumor immunity via NRF2-mediated mitophagy | Litcius