Divergence in CH alkylation of indoles under Mn catalysis
Akash Mondal, Rohit Kumar, Abhijith Karattil Suresh, Manoj Kumar Sahoo, Ekambaram Balaraman
Abstract
We report manganese-catalyzed CH alkylation of indole/indolines with alcohols, where catalyst control provides product selectivity. We synthesise several life science molecules (vibrindole A, turbomycin B alkaloid and antileukemic and anticancer agents).
Topics & Concepts
AlkylationCatalysisIndole testManganeseChemistrySelectivityCombinatorial chemistryMoleculeOrganic chemistryAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization MethodsChemical Synthesis and Analysis