Solvent Induced Conversion of a Self‐Assembled Gyrobifastigium to a Barrel and Encapsulation of Zinc‐Phthalocyanine within the Barrel for Enhanced Photodynamic Therapy
Valiyakath Abdul Rinshad, Jagabandhu Sahoo, Mangili Venkateswarulu, Neal Hickey, Mrinmoy De, Partha Sarathi Mukherjee
Abstract
Abstract A rare gyrobifastigium architecture ( GB ) was constructed by self‐assembly of a tetradentate donor ( L ) with Pd II acceptor in DMSO. The GB was converted to its isomeric tetragonal barrel ( MB ) upon treatment with water. The hydrophobic cavity of MB has been explored for the encapsulation of zinc‐phthalocyanine ( ZnPc ), which is an excellent photosensitizer for photodynamic therapy (PDT). However, the poor water‐solubility and aggregation tendency are the main reasons for the suboptimal PDT performance of free ZnPc in the aqueous medium. Effective solubilization of ZnPc in an aqueous medium was achieved by encapsulating it in the cavity of MB . The inclusion complex ( ZnPc⊂MB ) showed enhanced singlet oxygen generation in water. Higher cellular uptake and anticancer activity of the ZnPc⊂MB compared to free ZnPc on HeLa cells indicate that encapsulation of ZnPc in an aqueous host is a potential strategy for enhancement of its PDT activity in water.