Targeting KEAP1/Nrf2, AKT, and PPAR-γ signals as a potential protective mechanism of diosmin against gentamicin-induced nephrotoxicity
Fares E.M. Ali, Ahmed M. Sayed, Ali H. El‐Bahrawy, Zainab Omar, Emad H. M. Hassanein
Topics & Concepts
NephrotoxicityPharmacologyKEAP1GentamicinMechanism (biology)Protein kinase BDiosminPI3K/AKT/mTOR pathwayMedicineChemistryKidneyInternal medicineBiochemistrySignal transductionAntibioticsAntioxidantFlavonoidTranscription factorGeneEpistemologyPhilosophyAntibiotics Pharmacokinetics and EfficacyChemotherapy-induced organ toxicity mitigationDrug-Induced Hepatotoxicity and Protection