Heterologous Biosynthesis of Tetrahydroxanthone Dimers: Determination of Key Factors for Selective or Divergent Synthesis
Xingxing Wei, Xiaoxuan Chen, Lin Chen, Dexiu Yan, Wei‐Guang Wang, Yudai Matsuda
Abstract
requires highly selective preparation of the tetrahydroxanthone monomer, which is apparently controlled by AacuH. This study facilitates engineered biosynthesis of tetrahydroxanthone dimers both in a selective and divergent manner.
Topics & Concepts
BiosynthesisAspergillus oryzaeEnzymeBiochemistryHeterologous expressionHeterologousMonooxygenaseGene clusterStereochemistryChemistrySubstrate (aquarium)Nonribosomal peptideBiologyGeneCytochrome P450Recombinant DNAEcologyFungal Biology and ApplicationsPolysaccharides and Plant Cell WallsMicrobial Natural Products and Biosynthesis