Iron uptake mediated by the plant-derived chelator nicotianamine in the small intestine
Yoshiko Murata, Masami Yoshida, Naho Sakamoto, Shiho Morimoto, Takehiro Watanabe, Kosuke Namba
Abstract
Fe (or NA) was detected in the duodenum, where the divalent metal transporter SLC11A2 (DMT1) absorbs free Fe (II). The collective results revealed the role of PAT1 in NA-Fe (II) absorption in the intestine and potential implication of NA in iron uptake in mammals.
Topics & Concepts
ChelationChemistrySmall intestineBotanyEnvironmental chemistryBiologyBiochemistryInorganic chemistryCassava research and cyanideHeavy Metal Exposure and ToxicityIron Metabolism and Disorders