Copper-Catalyzed Azide–Alkyne Cycloaddition of Hydrazoic Acid Formed <i>In Situ</i> from Sodium Azide Affords 4-Monosubstituted-1,2,3-Triazoles
Dominik Jankovič, Miha Virant, Martin Gazvoda
Abstract
in <6% concentrations at which it is safe to handle. Reactions of distilled solutions of hydrazoic acid indicated its role as a reactive species in the copper-catalyzed reaction.
Topics & Concepts
Hydrazoic acidSodium azideChemistryCycloadditionAlkyneCatalysisAzideCopperCombinatorial chemistryOrganic chemistryClick Chemistry and ApplicationsChemical Synthesis and AnalysisPeptidase Inhibition and Analysis