Design, synthesis and biological evaluation of edaravone derivatives bearing the <i>N</i>-benzyl pyridinium moiety as multifunctional anti-Alzheimer’s agents
Luke S. Zondagh, Sarel F. Malan, Jacques Joubert
Abstract
studies indicated that these compounds should cross the blood-brain barrier, making them promising lead molecules in the development of anti-Alzheimer's agents.
Topics & Concepts
EdaravoneAcetylcholinesterasePyridiniumChemistryMoietyAchéButyrylcholinesteraseNeuroprotectionIC50StereochemistryAntioxidantActive siteStructure–activity relationshipCombinatorial chemistryIn vitroPharmacologyBiochemistryEnzymeMedicinal chemistryMedicineCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsAlzheimer's disease research and treatments