Inducible nitric oxide synthase activity mediates TNF-α-induced endothelial cell dysfunction
Chen Liu, Sujuan Lei, Tianying Cai, Yonglang Cheng, Junjie Bai, Wenguang Fu, Meizhou Huang
Abstract
Inducible nitric oxide synthase (iNOS) deficiency during vascular endothelial dysfunction may affect the expression of tumor necrosis factor receptor-2 and vascular adhesion factors via cellular metabolic changes, thereby attenuating vascular endothelial dysfunction.
Topics & Concepts
Nitric oxide synthaseNitric oxideEndothelial nitric oxide synthaseEndothelial dysfunctionChemistryTumor necrosis factor alphaCellEndothelial stem cellCell biologyPharmacologyBiochemistryMedicineInternal medicineBiologyEnosIn vitroOrganic chemistryNitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative MechanismsEicosanoids and Hypertension Pharmacology