Hetero-Diels–Alder reactions of 2<i>H</i>-phospholes with allenes: synthesis and functionalization of 6-methylene-1-phosphanorbornenes
Keke Zhang, Qiaoyu Zhang, Donghui Wei, Rongqiang Tian, Zheng Duan
Abstract
The phospha-Diels–Alder reaction between 2<italic>H</italic>-phospholes and arylallenes affords 6-methylene-1-phosphanorbornenes in high yields with excellent regioselectivity. Further functionalization provides a 1-phosphanorbornene modified PCH<sub>2</sub>CH<sub>2</sub>P skeleton.
Topics & Concepts
ChemistryRegioselectivityMethyleneDiels–Alder reactionSurface modificationStereochemistryMedicinal chemistryOrganic chemistryCatalysisPhysical chemistrySynthesis and characterization of novel inorganic/organometallic compoundsOrganophosphorus compounds synthesisAsymmetric Hydrogenation and Catalysis