Tobacco and electronic cigarettes adversely impact ECG indexes of ventricular repolarization: implication for sudden death risk
Michelle Ip, Evangelos Diamantakos, Kacey Haptonstall, Yasmine Choroomi, Roya Moheimani, Kevin Nguyen, Elizabeth Tran, Jeffrey Gornbein, Holly R. Middlekauff
Abstract
Abnormal ventricular repolarization, as indicated by prolonged Tpeak-end (Tp-e), is associated with increased sudden death risk. Baseline ECG indexes of repolarization, Tp-e, Tp-e/QT, and Tp-e/QTc, were not different among tobacco cigarette (TC) smokers, electronic cigarette (EC) users, and nonsmokers at baseline, but when TC smokers smoked one TC, all parameters were prolonged. Using an electronic cigarette with nicotine, but not without nicotine, increased the Tp-e/QT. Smoking induces changes in ECG indexes of ventricular repolarization associated with increased sudden death risk.
Topics & Concepts
CardiologySudden deathVentricular RepolarizationBenign early repolarizationRepolarizationMedicineSudden cardiac deathInternal medicineMyocardial infarctionElectrophysiologyST segmentCardiac electrophysiology and arrhythmiasCardiovascular Effects of ExerciseECG Monitoring and Analysis