The onset of <i>de novo</i> autoantibodies in healthcare workers after mRNA based anti-SARS-CoV-2 vaccines: a single centre prospective follow-up study
Maria Cristina Sacchi, Carolina Pelazza, Marinella Bertolotti, Lisa Agatea, Piera De Gaspari, Stefania Tamiazzo, Domenico Ielo, Paolo Stobbione, M. Grappiolo, Tatiana Bolgeo, Patricia Novel, Mark Ciriello, Antonio Maconi
Abstract
ANA in 22/77(28,57%) of subjects and that the percentage of positivity seems to be directly correlated to the number of vaccine expositions: 6/77 (7,79%) after 2 doses; 16/77 (20,78%) after 3 doses. Since it is known that hyperstimulation of the immune system could lead to autoimmunity, these preliminary results seem to further sustain the idea that the hyperstimulation of the immune system might lead to an autoinflammatory mechanism and eventually to autoimmune disorders. However, the link between SARS-CoV-2 vaccination and the development of autoimmune diseases needs to be further investigated.