The Role of Histone Modifications in the Pathogenesis of Diabetic Kidney Disease
Christodoula Kourtidou, Κωνσταντίνος Τζιόμαλος
Abstract
Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease. The pathogenesis of DKD is multifactorial, with several molecular pathways implicated. Recent data suggest that histone modification plays an important role in the development and progression of DKD. Histone modification appears to induce oxidative stress, inflammation and fibrosis in the diabetic kidney. In the present review, we summarize the current knowledge on the association between histone modification and DKD.
Topics & Concepts
PathogenesisHistoneMedicineDiseaseInflammationKidneyKidney diseaseOxidative stressFibrosisBioinformaticsImmunologyBiologyInternal medicineGeneticsGeneEpigenetics and DNA MethylationChronic Kidney Disease and DiabetesAdenosine and Purinergic Signaling