Mitochondria as an important target of metformin: The mechanism of action, toxic and side effects, and new therapeutic applications
Jin Feng, Xiaohui Wang, Xiaochun Ye, Irma Arés, Bernardo López-Torres, Marta Martínez, María‐Rosa Martínez‐Larrañaga, Xu Wang, Arturo Anadón, María‐Aránzazu Martínez
Topics & Concepts
MetforminMitochondrionRepurposingDrug repositioningDrugMechanism (biology)PharmacologyMechanism of actionMedicineMitochondrial respiratory chainRespiratory chainBiologyDiabetes mellitusCell biologyEndocrinologyBiochemistryIn vitroEpistemologyPhilosophyEcologyMetabolism, Diabetes, and CancerPancreatic function and diabetesCancer, Hypoxia, and Metabolism