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Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data

Martin Jinye Zhang, Kangcheng Hou, Kushal K. Dey, Saori Sakaue, Karthik A. Jagadeesh, Kathryn Weinand, Aris Taychameekiatchai, Poorvi Rao, Angela Oliveira Pisco, James Zou, Bruce Wang, Michael J. Gandal, Soumya Raychaudhuri, Bogdan Paşaniuc, Alkes L. Price

2022Nature Genetics271 citationsDOIOpen Access PDF

Topics & Concepts

BiologyRNA-SeqGeneticsDiseaseComputational biologyCellRNATranscriptomeGene expressionGeneInternal medicineMedicineSingle-cell and spatial transcriptomicsExtracellular vesicles in diseaseAtherosclerosis and Cardiovascular Diseases
Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data | Litcius