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Erdafitinib promotes ferroptosis in human uveal melanoma by inducing ferritinophagy and lysosome biogenesis via modulating the FGFR1/mTORC1/TFEB signaling axis

Xue Zhu, Ling Wang, Ke Wang, Ying Yao, Fanfan Zhou, Fanfan Zhou

2024Free Radical Biology and Medicine17 citationsDOI

Topics & Concepts

TFEBmTORC1LysosomeCancer researchCell biologyBiologyPI3K/AKT/mTOR pathwaySignal transductionBiochemistryEnzymeEpigenetics and DNA MethylationUbiquitin and proteasome pathwaysFerroptosis and cancer prognosis
Erdafitinib promotes ferroptosis in human uveal melanoma by inducing ferritinophagy and lysosome biogenesis via modulating the FGFR1/mTORC1/TFEB signaling axis | Litcius