Ovariectomy aggravates the pathophysiological response to exertional heat stroke in mice
Liliana I. Rentería, Xiangyu Zheng, Isela Valera, Daniel R. Machin, Christian K. Garcia, Lisa R. Leon, Orlando Laitano
Abstract
Females outperform males in a mouse model of exertional heat stroke (EHS). Here, we show for the first time the impact of ovariectomy (OVX) on EHS pathophysiology. OVX resulted in a shorter exercise capacity in the heat, greater intestinal damage, and lower heat shock response following EHS.
Topics & Concepts
PathophysiologyMedicineHeat exhaustionStroke (engine)ThermoregulationInternal medicineCardiologyPhysical medicine and rehabilitationEndocrinologyPoison controlMedical emergencyMechanical engineeringEngineeringThermoregulation and physiological responsesExercise and Physiological ResponsesMuscle metabolism and nutrition