Expression and function of transient receptor potential melastatin 3 in the spinal afferent innervation of the mouse colon
James W. King, Aidan S. Bennett, Hannah M. Wood, Corey C. Baker, Hanin Alsaadi, Max Topley, Stephen A. Vanner, David E. Reed, Alan Lomax
Abstract
This is the first study to characterize TRPM3 protein expression and function in colon-projecting DRG neurons. A TRPM3 agonist excited DRG neurons and colonic afferent nerves from healthy mice. TRPM3 agonist responses in DRG neurons were elevated during colitis. Inhibiting TRPM3 reduced the firing of wide dynamic range afferent nerves from mice with colitis but had no effect in control mice.
Topics & Concepts
AgonistTransient receptor potential channelReceptorAfferentColitisNeuroscienceChemistryMedicineEndocrinologyInternal medicineBiologyIon Channels and ReceptorsGastrointestinal motility and disordersMagnesium in Health and Disease