Synthesis and biological evaluation of dehydroabietic acid-pyrimidine hybrids as antitumor agents
Lin Huang, Rong Huang, Fuhua Pang, Anke Li, Guobao Huang, Xiaoqun Zhou, Qian Li, Fangyao Li, Xian‐Li Ma
Abstract
values ranging from 7.00 to 11.93 μM against all the tested cell lines and displayed weak cytotoxicity towards normal cells. Besides, cell cycle analysis indicated that compound 3b mainly arrested MCF-7 cells at the S stage and induced cell apoptosis.
Topics & Concepts
PyrimidineHybridChemistryCombinatorial chemistryStereochemistryPharmacologyBiologyBotanyBiological Activity of Diterpenoids and BiflavonoidsNatural product bioactivities and synthesisFree Radicals and Antioxidants