Advances in transition-metal catalyzed C–H bond activation of amidines to synthesize aza-heterocycles
Jie Ren, Yijia Xiong, Qian Li, Bin Wang, Guanglu Wang, Bingyang Wang, Huimin Liu, Xuepeng Yang
Abstract
the more basic and less sterically crowded imino lone pair and coordinate with transition-metals, in which N-H imine could act as both directing group and intramolecular nucleophile, electrophile or proton acceptor. The mechanisms of different annulation pathways will be highlighted in this review along with a discussion of more recent developments in the field.
Topics & Concepts
AmidineChemistryCatalysisTransition metalMoleculeCombinatorial chemistryNitrogenOrganic chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsAsymmetric Hydrogenation and Catalysis