Total Synthesis of an All-1,2-<i>cis</i>-Linked Repeating Unit from the <i>Acinetobacter baumannii</i> D78 Capsular Polysaccharide

Abstract

Chemical synthetic efforts have resulted in the preparation of the assigned tetrasaccharide repeating subunit from the Acinetobacter baumannii KL4-associated capsular polysaccharide. A convergent synthetic strategy hinging on a 1,2-cis-selective [2+2] glycosylation to generate the fully protected tetrasaccharide was key to the success of this synthesis.

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