Spinal cord fractalkine (CX3CL1) signaling is critical for neuronal sensitization in experimental nonspecific, myofascial low back pain
Katharina Sessler, Vivian Blechschmidt, Ulrich Hoheisel, Siegfried Mense, Lucas Schirmer, Rolf‐Detlef Treede
Abstract
Blocking fractalkine signaling by neutralizing antibodies completely prevented spinal sensitization induced by repetitive mild nociceptive input [2 nerve growth factor (NGF) injections into the multifidus muscle] Conversely, fractalkine given intrathecally caused the same pattern of spinal sensitization as the nociceptive NGF injections. Fractalkine signaling is critically involved in sensitization of dorsal horn neurons induced by repeated nociceptive low back muscle stimulation and may hence be a potential target for the prevention of nonspecific, myofascial low back pain.
Topics & Concepts
CX3CR1MedicineSensitizationSpinal cordNeuroscienceMicrogliaReceptive fieldNociceptionStimulationReceptorInternal medicineInflammationImmunologyBiologyChemokineChemokine receptorPain Mechanisms and TreatmentsNeuropeptides and Animal PhysiologyPharmacological Effects of Natural Compounds