Enhancing the bystander effect of antibody-drug conjugate by using a novel caspase-3 cleavable peptide linker to overcome tumor heterogeneity
Ha Kyeong Lee, Byoungmo Kim, Yoon Gun Ko, Seung Woo Chung, Wan Seob Shim, Soyoung Choi, Se-Ra Lee, Sang Yoon Kim, Youngro Byun
Topics & Concepts
Bystander effectAntibody-drug conjugateConjugatePeptideLinkerDrugAntibodyChemistryCancer researchPharmacologyComputational biologyMedicineImmunologyBiologyMonoclonal antibodyBiochemistryComputer scienceOperating systemMathematicsMathematical analysisHER2/EGFR in Cancer ResearchMonoclonal and Polyclonal Antibodies ResearchRadiopharmaceutical Chemistry and Applications