Design, synthesis, and biological evaluation of novel 4-(4-ethoxyphenyl)-6-(substituted-phenyl)pyrimidin-2-amine/thiol/hydroxy derivatives as EGFRWT and EGFRT790M inhibitors targeting NSCLC: In-vitro and in-silico exploration
Rohit Pal, Gurubasavaraja Swamy Purawarga Matada, Ghanshyam Teli, Viney Chawla, Pooja A. Chawla
Topics & Concepts
ChemistryIn silicoAmine gas treatingThiolIn vitroCombinatorial chemistryOrganic chemistryBiochemistryGeneLung Cancer Treatments and MutationsSynthesis and biological activityCytokine Signaling Pathways and Interactions