RNA-binding motif protein 10 represses tumor progression through the Wnt/β- catenin pathway in lung adenocarcinoma
Yingyue Cao, Jianxiong Geng, Xin Wang, Qingwei Meng, Shanqi Xu, Yaoguo Lang, Yongxu Zhou, Lishuang Qi, Zijie Wang, Zixin Wei, Yan Yu, Jin Shi, Bo Pan
Abstract
RNA-binding motif protein 10 (RBM10), one of the members of the RNA-binding protein (RBP) family, has a tumor suppressor role in multiple cancers. However, the functional role of RBM10 in lung adenocarcinoma (LUAD) and the underlying molecular mechanism remains unclear. In this study, we observed that RBM10 is significantly downregulated in LUAD tissues compared with normal tissues. Low RBM10 expression is significantly associated with poor outcome of LUAD patients. In vitro and in vivo experiments show that RBM10 inhibits cell proliferation, metastasis and EMT progression in LUAD. Mechanistically, we demonstrate that RBM10 interacts with -catenin interacting protein 1 (CTNNBIP1) and positively regulates its expression, disrupting the binding of -catenin to the transcription factor TCF/LEF, thereby inactivating the Wnt/-catenin pathway. In conclusion, this is the first study reporting the role of RBM10 in suppressing LUAD progression at least via partly inactivating the Wnt/-catenin pathway, which provides new insights into the tumorigenesis and metastasis of LUAD. Thus, RBM10 may be a promising new therapeutic target or clinical biomarker for LUAD therapy in the future.