Glycan–protein interactions determine kinetics of <i>N</i> -glycan remodeling
Corina Mathew, Richard Weiß, Christoph Giese, Chia‐Wei Lin, Marie‐Estelle Losfeld, Rudi Glockshuber, Sereina Riniker, Markus Aebi
Abstract
-glycan reactivities depend on the surrounding protein tertiary structure and lead to different glycan structures in the same protein through kinetically controlled processing pathways.
Topics & Concepts
GlycanKineticsChemistryGlycoproteinMass spectrometryEnzyme kineticsBiochemistryEnzymeChromatographyActive sitePhysicsQuantum mechanicsGlycosylation and Glycoproteins ResearchEnzyme Structure and FunctionProtein Structure and Dynamics