Non-invasive activation of intratumoural gene editing for improved adoptive T-cell therapy in solid tumours
Xiaohong Chen, Shuang Wang, Yuxuan Chen, Huhu Xin, Shuaishuai Zhang, Di Wu, Yanan Xue, Menglei Zha, Hongjun Li, Kai Li, Zhen Gu, Wei Wei, Ping Yuan
Topics & Concepts
Cancer researchAdoptive cell transferGenome editingTumor microenvironmentImmunotherapyCas9Cell therapyCRISPRImmune systemApoptosisChimeric antigen receptorT cellBiologyCell biologyImmunologyGeneStem cellBiochemistryCAR-T cell therapy researchVirus-based gene therapy researchCRISPR and Genetic Engineering