Chromium-Catalyzed Three-Component Synthesis of Monofluoroalkenes from <i>gem</i>-Difluoroalkenes via C–O/C–H and C–F Bond Activation
Ya Xiong, Meiming Luo, Xiaoming Zeng
Abstract
We report here the chromium-catalyzed three-component defluorinative cross-couplings of gem -difluoroalkenes with benzyl 2-pyridinyl ethers and aryl Grignard reagents under mild conditions, enabling the convenient synthesis of diarylmethylated monofluoroalkenes in good chemo- and stereoselectivity.
Topics & Concepts
ChemistryCatalysisArylStereoselectivityReagentChromiumComponent (thermodynamics)Grignard reagentCombinatorial chemistryMedicinal chemistryOrganic chemistryStereochemistryAlkylPhysicsThermodynamicsFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsRadical Photochemical Reactions