Coumarin–carbazole based functionalized pyrazolines: synthesis, characterization, anticancer investigation and molecular docking
Mrugesh Patel, Nilesh Pandey, Jignesh B. Timaniya, Paranjay Parikh, Alex Chauhan, Neeraj Jain, Kaushal P. Patel
Abstract
cytotoxicity study of all the synthesized compounds was evaluated against HeLa, NCI-H520 and NRK-52E cell lines. Compounds 4a and 7b became the most active compounds and exhibited their potential to arrest the cell cycle progression and induce apoptosis in both the cell lines. In addition, molecular docking studies revealed a higher binding affinity of both the molecules with CDK2 protein. Based on the obtained results, a comprehensive analysis is warranted to establish the role of compounds 4a and 7b as promising cancer therapeutic agents.
Topics & Concepts
ChemistryPyrazolineHeLaCoumarinCarbazoleCarbon-13 NMRDocking (animal)CytotoxicityCombinatorial chemistryProton NMRStereochemistryAmideOxadiazoleIn vitroBiochemistryOrganic chemistryNursingMedicineSynthesis and biological activityMulticomponent Synthesis of HeterocyclesBioactive Compounds and Antitumor Agents