Antimicrobial activity of new benzazolyl N-sulfonyl amidines
Nadezhda A. Galieva, Dmitriy A. Saveliev, Oleg S. Eltsov, Vasiliy А. Bakulev, Gert Lübec, Jihong Xing, Zhijin Fan, Tetyana Beryozkina
Abstract
The reactions of N -(benz[ d ]oxazol-2-yl)- or N -(benzo[ d ]-thiazol-2-yl)-substituted carbothioamides with sulfonyl azides proceed as replacement of thioxo substituent by the sulfonylimino group to afford the corresponding N' -sulfonylated amidines. Acetic acid thioamides react smoothly upon boiling in ethanol, while for thioamides of trifluoroacetic and benzoic acids heating to 80–90 °C was required. Among hybrid molecules thus prepared, bacteriostatic-, bactericidal- and fungistatic-active against S. aureus and C. albicans representatives were found.
Topics & Concepts
ChemistrySulfonylAntimicrobialBenzoic acidAcetic acidSubstituentTrifluoroacetic acidCandida albicansOrganic chemistryMedicinal chemistryCombinatorial chemistryAlkylGeneticsBiologyQuinazolinone synthesis and applicationsSynthesis and Catalytic ReactionsSulfur-Based Synthesis Techniques