Neuroprotective Effect of Carnosine Is Mediated by Insulin-Degrading Enzyme
Alessia Distefano, Giuseppe Caruso, Valentina Oliveri, Francesco Bellia, Diego Sbardella, Gabriele Antonio Zingale, Filippo Caraci, Giuseppe Grasso
Abstract
l-Carnosine is an endogenous dipeptide that has high potential for therapeutic purposes, being an antioxidant with metal chelating, anti-aggregating, anti-inflammatory, and neuroprotective properties. Despite its potential therapeutic values, the biomolecular mechanisms involved in neuroprotection are not fully understood. Here, we demonstrate, at chemical and biochemical levels, that insulin-degrading enzyme plays a pivotal role in carnosine neuroprotection.
Topics & Concepts
NeuroprotectionCarnosineDipeptidePharmacologyChemistryAntioxidantEnzymeEndogenyInsulinBiochemistryBiologyPeptideEndocrinologyBiochemical effects in animalsFree Radicals and AntioxidantsStress Responses and Cortisol