Pegylated Curcumin Derivative: Water-Soluble Conjugates with Antitumor and Antibacterial Activity
Guldjan Yakub, Nevena Manolova, Iliya Rashkov, Nadya Markova, Reneta Toshkova, Ani Georgieva, Rosica Mincheva, Antoniya Toncheva, Jean‐Marie Raquez, Philippe Dúbois
Abstract
. Most importantly, despite the covalent attachment of Curc to PEG and the slight reduction in the therapeutic index of the conjugate, both the anticancer and antimicrobial activities remain the highest reported, thus opening the gate for further, more clinically oriented studies.
Topics & Concepts
CurcuminNuclear chemistryConjugateEthylene glycolProton NMRAntibacterial activityCombinatorial chemistryFourier transform infrared spectroscopyChemistryMaterials scienceOrganic chemistryBiochemistryChemical engineeringBacteriaBiologyGeneticsEngineeringMathematical analysisMathematicsCurcumin's Biomedical ApplicationsNatural product bioactivities and synthesisPolydiacetylene-based materials and applications