Identification of 2-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)amino)-N-phenylpropanamides as a novel class of potent DprE1 inhibitors
Benjamin C. Whitehurst, Robert J. Young, Glenn A. Burley, Mónica Cacho, Pedro Henrique Monteiro Torres, Laura Vela-Gonzalez del Peral
Topics & Concepts
ChemistryAntimycobacterialStereochemistryIdentification (biology)Structure–activity relationshipChemical synthesisCombinatorial chemistryIn vitroBiochemistryMycobacterium tuberculosisTuberculosisBiologyPathologyMedicineBotanyTrace Elements in HealthCell death mechanisms and regulationRNA and protein synthesis mechanisms