PINK1-PRKN mediated mitophagy: differences between <i>in vitro</i> and <i>in vivo</i> models
Rui Han, Yanting Liu, Shihua Li, Xiao‐Jiang Li, Weili Yang
Abstract
: AAV: adeno-associated viruses;AD: Alzheimer disease; CCCP: carbonyl cyanidem-chlorophenyl hydrazone; HD: Huntington disease; MPTP: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MTS: mitochondrial targeting sequence; PD: Parkinson diseases; PINK1: PTEN induced kinase 1; PRKN: parkin RBR E3 ubiquitin protein ligase; ROS: reactive oxygen species; UIM, ubiquitin interacting motif.
Topics & Concepts
MitophagyBiologyPINK1In vivoAutophagyIn vitroCell biologyNeuroscienceApoptosisGeneticsAutophagy in Disease and TherapyParkinson's Disease Mechanisms and TreatmentsMetabolism, Diabetes, and Cancer