Clinical implementation of pharmacogenetics and personalized drug prescription based on e-health: the MedeA initiative
Adrián LLerena, Eva Peñas‐Lledó, Fernando de Andrés, Carmen Mata-Martín, Cristina Matesanz López, A. Pijierro-Amador, J. Cobaleda
Abstract
There is a growing demand for the clinical implementation \nof pharmacogenetics (PGx), personalized and precision \nmedicine (PPM) for drug prescription to reduce adverse \ndrug reactions (ADRs), drug failure, and ultimately health \ncare costs. However, it is convenient to clarify the concept \nof clinical implementation to realize its benefits. Advances \non PGx clinical implementation depend on the integration \nof genetic along with other relevant biomarkers and clinical information influencing variability in drug response \nfor being interpreted and translated into clinical decisionmaking to optimize drug treatment choice during routine \nclinical practice.