Extending traditional antibody therapies: Novel discoveries in immunotherapy and clinical applications
Charles Shin, Sung Soo Kim, Yong Hwa Jo
Abstract
trials, and clinical applications. Here, we have looked around antibodies overall. First, we elucidate the antibody structure and its cytotoxicity mechanisms. Second, types of therapeutic antibodies are presented. Additionally, there is a summarized list of US Food and Drug Administration (FDA)-approved therapeutic antibodies and recent clinical trials. This review provides a comprehensive overview of both the general function of therapeutic antibodies and a few main variations in development, including recent advent with the proposed mechanism of actions, and we introduce types of therapeutic antibodies, clinical trials, and approved commercial immunotherapeutic drugs.
Topics & Concepts
ImmunotherapyMedicineAntibodyMonoclonal antibodyAntibody-drug conjugateClinical trialCancer immunotherapyAntigenCancerImmunologyImmune systemInternal medicineMonoclonal and Polyclonal Antibodies ResearchCAR-T cell therapy researchBiosimilars and Bioanalytical Methods