Platelets Inhibit Methicillin-Resistant Staphylococcus aureus by Inducing Hydroxyl Radical-Mediated Apoptosis-Like Cell Death
Erxiong Liu, Yutong Chen, Jinmei Xu, Shunli Gu, Ning An, Jiajia Xin, Wenting Wang, Zhixin Liu, Qunxing An, Jing Yi, Wen Yin
Abstract
. Our results revealed that platelets enhanced the production of hydroxyl radicals in MRSA, which induced a series of apoptosis hallmarks in MRSA, including DNA fragmentation, chromosome condensation, phosphatidylserine exposure, membrane potential depolarization, and increased intracellular caspase activity. These findings may further our understanding of platelet function.
Topics & Concepts
ApoptosisStaphylococcus aureusMethicillin-resistant Staphylococcus aureusChemistryProgrammed cell deathMicrobiologyHydroxyl radicalCancer researchBiologyBacteriaBiochemistryRadicalGeneticsAntimicrobial Resistance in StaphylococcusBacterial biofilms and quorum sensingAntibiotics Pharmacokinetics and Efficacy