Synthesis of medium-ring lactams and macrocyclic peptide mimetics <i>via</i> conjugate addition/ring expansion cascade reactions
Kleopas Y. Palate, Zhongzhen Yang, Adrian C. Whitwood, William P. Unsworth
Abstract
A conjugate addition/ring expansion (CARE) cascade reaction sequence is reported that enables medium-sized ring and macrocyclic bis-lactams to be prepared from primary amines and cyclic imides.
Topics & Concepts
PeptoidConjugateRing (chemistry)Combinatorial chemistryChemistryAmine gas treatingCascadePeptideCascade reactionSequence (biology)StereochemistryOrganic chemistryCatalysisMathematicsMathematical analysisBiochemistryChromatographyChemical Synthesis and AnalysisSynthetic Organic Chemistry MethodsSynthesis and Catalytic Reactions